Director Clinical Science

Job Description

Director, Clinical Sciences

Location: Southern California

Work Type: Hybrid 

Position Overview

The Director, Clinical Sciences will act as a key scientific contributor in the planning and delivery of clinical-stage programs. This individual will collaborate with both internal cross-functional teams and external experts to ensure high scientific standards and the successful execution of studies.

About the Company

A pioneering biotech that specializes in precision drug discovery through a proprietary chemical proteomics platform. Our innovative approach enables comprehensive mapping of drug-target interactions across the proteome, offering novel ways to identify and develop treatments that engage previously "undruggable" proteins.

Focused primarily on oncology, our portfolio includes first-in-class compounds that employ unique mechanisms of action, ranging from allosteric inhibitors and PPI disruptors to degraders and molecular activators.

We’re committed to cutting-edge science, creativity, and collaboration. Here, contributions matter. Our environment supports mentorship, career growth, and a shared drive to push the boundaries of modern medicine.

Key Responsibilities

• Design clinical studies and protocols in close partnership with internal stakeholders and external advisors
• Contribute to statistical plans and lead the creation of study documents including consent forms, operations manuals, safety plans, and data management strategies
• Support data quality and integrity through case report form (CRF) design, clinical review, and resolution of data queries
• Identify trends in clinical data and escalate findings to the medical lead when necessary
• Assist in the development of clinical narratives and support narrative reviews
• Provide input to budget development and vendor scopes, supporting protocol managers with required scientific content
• Lead or contribute to the creation of training materials and present at site initiation visits or investigator meetings
• Serve as a key point of contact for site-level clinical questions
• Assist in the preparation and review of regulatory submissions, including CSRs, investigator brochures, and safety reports
• Engage with KOLs and external partners for strategic input and scientific dialogue
• Support governance of oversight bodies such as data monitoring committees and dose review teams

Qualifications and Skills

• Advanced scientific or medical degree (MD, PhD, or PharmD preferred)
• At least 8 years of experience in clinical science or clinical research within biotech, pharma, or CRO environments
• Solid grounding in ICH/GCP standards and the broader drug development lifecycle
• Strong understanding of clinical trial methodology, biostatistics, and operational requirements
• Experience in clinical data review and ability to identify and interpret emerging trends
• Familiarity with the structure and function of oversight bodies such as adjudication or monitoring committees

#LI-OG1